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Development of direct acting antivirals DAA offers new benefits for patients with chronic hepatitis C. A simulation of drug-drug interactions between antiretroviral treatment and DAAs available in was performed.
A previous treatment against HCV had been administered in This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: All relevant data are within the paper and its Supporting Information files. He also participated in advisory board meetings for MSD. Beside classical risk factors like age or alcoholism, HIV infection is known to favor liver disease progression.
Until recently, treatment of chronic HCV infection was restricted to pegylated interferon PEG-IFN and ribavirin, leading to poor response rates and bad tolerability [ 5 ]. After , the association of first-generation HCV protease inhibitors boceprevir or telaprevir with PEG-IFN and ribavirin significantly increased the response rates in both naive and pre-treated patients leading to sustained virological response SVR rates similar to those observed in HCV mono-infected patients [ 6 β 8 ]. However, the tolerability of these regimens was poor, due to the cumulated toxicity of these first-generation direct acting antiviral agents DAAs and those of IFN and ribavirin.
Patient-related data are recorded during medical visits in a structured database, allowing the use of the database for clinical, epidemiological or therapeutic studies.
Data quality is ensured by automated checks during data capture, regular controls, annual assessments, and ad hoc processes before any scientific analysis is performed. For patients with successive fibrosis evaluations, the last score was retained for the study.