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Purpose: There are concerns within the medical profession that antimicrobial agents used in livestock production contribute to the increased antibiotic resistance observed in zoonotic bacterial pathogens. To minimise this risk, evidence-based control strategies need to be implemented. We investigated the effect of chlortetracycline treatment on a tetracycline resistant population of Salmonella typhimurium DT and the commensal Escherichia coli population in pigs.
Results: Our results show that pigs treated with chlortetracycline consistently shed higher numbers of resistant S. These effects persisted for up to 2 weeks post-treatment. The tetracycline resistance gene was characterised by gene probing and PCR.
The level of chlortetracycline in the pig faeces, as measured by HPLC, fell below our detection limit 5 days after treatment. Conclusion: This study provides direct evidence that oral administration of chlortetracycline to pigs significantly increases the proportion of resistant enteric bacteria, and this shift in resistance outlasts any residual chlortetracycline in the pig faeces.
Analysis of Helicobacter pylori resistance to antimicrobial agents in Polish children SoA4. Background: Helicobacter pylori resistance to antimicrobial agents is an important factor compromising the efficacy of therapy. Since initial treatment for H.
