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Gliomas are a complex and heterogeneous group of primary brain tumours. Mortality due to brain tumour has risen from 0. The low incidence of this disease has limited the amount of data available, particularly for treatment. The objective is to define guidelines for the management of adult patients with glioma. The management of spinal, non-glial, hypophyseal, neuronal tumours and schwannomas and the management of childhood glioma are not covered in this document.
The general methodology used has already been described Fervers et al, In addition, the members of the working group provided references from their personal sources up to The majority of the articles thus identified were in English or French. Many of the articles identified reported results for heterogeneous populations of patients adults and children, and types of glioma , and therefore, when possible, information had to be extracted for specific populations and tumours.
However, as this was not possible in all publications, not all the available literature could be analysed. The document was then peer-reviewed by independent experts, and their comments were integrated in the final version. These recommendations thus help clinicians to select an appropriate option. The adaptation of the SOR to the local situation is allowable if the reason for the choice is sufficiently transparent and this is crucial for successful implementation.
Inclusion of patients in clinical trials is an appropriate form of patient management in oncology and is recommended frequently within the SORs, particularly in situations where only weak evidence exists to support a procedure or an intervention. The level of evidence depends not only on the type and quality of the studies reviewed, but also on the concordance of the results Table 2.
