Official websites use. Share sensitive information only on official, secure websites. Correspondence: m. Patients in ICU had the highest SeptiScores, producing values comparable to 8 patients with culture-confirmed bacterial sepsis. SeptiScores increased with the extent of the lung injury. In contrast to C-reactive protein CRP , correlation of SeptiScore with lung injury was not impacted by treatment with anti-inflammatory agents.
Sepsis is a complex immuno-pathological disorder characterized by a pro-inflammatory response that may be followed by an anti-inflammatory, immunosuppressive state, or possibly a cycling between these states over several weeks [ 1 ]. It is now well-known that SARS-CoV-2 infection can progress to a severe disease characterized by a dysregulated immune response and a maladaptive cytokine release [ 3 ], leading to multiple complications including acute respiratory distress syndrome ARDS , myocarditis, acute kidney and liver failure and coagulopathy [ 4 ].
Therefore, there are important similarities of this severe disease progression to sepsis [ 5 , 6 , 7 , 8 ]. As such, Beltran-Garcia et al. Because of the multiplicity of mutations presented by omicron, this VOC exhibited enhanced transmissibility and immune-evasive properties [ 12 , 13 ].
More recently, novel recombinants have been detected, most likely arising from different variants replicating simultaneously in immunocompromised or unvaccinated individuals [ 14 , 15 ]. As of January , the highly transmissible and immune-evasive XBB1.
In public health terms, the appearance of each new variant with immune-evasive properties is characterized by rapid and massive contamination of patients, who arrive in large numbers in the emergency department ED. Severity of the disease is evaluated by different biological parameters such as lymphopenia, blood oxygen saturation, C-reactive protein CRP levels and D-dimer levels [ 16 ].
