Official websites use. Share sensitive information only on official, secure websites. Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited.
In the present study, we established hematologic and biochemical reference intervals for healthy cynomolgus and rhesus monkeys anesthetized with ketamine hydrochloride. A total of cynomolgus monkeys 28 males and females and 42 rhesus monkeys 22 males and 20 females were selected and analyzed in order to examine reference intervals of 20 hematological and 16 biochemical parameters. The effects of sex were also investigated. Reference intervals for hematological and biochemical parameters were separately established by species cynomolgus and rhesus and sex male and female.
(mh=657GgC_GE6KarTll)13415122a.jpg "Sluts Bourges")
No sex-related differences were determined in erythrocyte-related parameters for cynomolgus and rhesus monkey housed in indoor laboratory conditions. The reference values for hematological and biochemical parameters established herein might provide valuable information for researchers using cynomolgus and rhesus monkeys in experimental conditions for biomedical studies.
Non-human primates NHPs are valid and indispensable animal models for biomedical research because humans and NHPs are similar in behavior, physiology, and organ function. Additionally, the immune systems of NHPs are more similar genetically to humans than other animal models such as rodents, rabbits, and dogs. The cynomolgus Macaca fascicularis and the rhesus macaque Macaca mulatta are the most widely used NHP models in various biomedical research fields, including genomic analysis [ 3 ] and neurodegenerative disease [ 4 , 5 ], as well as reproductive biomedical research [ 6 β 8 ].
As a result of the increased use of cynomolgus and rhesus monkeys in biomedical research, it is necessary to establish the hematological and biochemical parameters of these monkey species. Reference values are imperative to support the selection of healthy animals and to interpret laboratory data in NHP models.
