Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Benign prostatic hyperplasia BPH is a chronic, progressive disease characterized by mesenchymal cell-predominance and stromal and glandular cell-hyperproliferation.
Although, the precise cause of BPH is unknown, it is believed to be associated with hormonal changes in aging men. Despite androgens and ageing are likely to play a role in the development of BPH, the pathophysiology of BPH remains uncertain.
This paper aims to evaluate the diagnostic efficacy of platelet-to-lymphocyte ratio PLR , neutrophilβlymphocyte ratio NLR and systemic immune-inflammation index in in diagnosing BPH. A single-center-randomized-retrospective study was carried out at Alzahraa university hospital between January and November on 80 participants 40 non-BPH subjects and 40 patients with symptomatic enlarged prostate who visited the outpatient clinic or admitted to the urology department.
The medical term for an enlarged prostate that can affect how men urine is benign prostatic hyperplasia BPH 1. Although the specific cause of BPH is unknown, it is believed to be related to hormonal changes that occur in men as they age. BPH is a chronic, progressive disease marked by mesenchymal cell predominance and stromal and glandular cells hyperproliferation 2. Recent clinical investigations have revealed a connection between prostatic inflammations and lower urinary tract symptoms LUTS associated with BPH 3 , 4 , and over the past few years, it has become clear that inflammation may play a significant role in the development and progression of BPH 5 , 6.
Consequently, it has been proposed that BPH is an inflammatory immune-mediated condition, and that inflammation may directly influence prostate growth 7 , 8. The autonomic nervous system regulates the adult prostate gland's physiological processes, while hormones control the gland's growth and development. The hypogastric nerve sends sympathetic signals to the prostate gland, whereas the pelvic nerve sends parasympathetic signals.
