Official websites use. Share sensitive information only on official, secure websites. Correspondence: lauren. Cancer is a leading cause of death, both in the general population and in people with HIV. Amongst almost 65, individuals, we found that the age-standardised incidence of all cancers remained fairly constant over time; however, the incidence of ADCs and infection-related cancers both decreased, whilst the incidence of NADCs, smoking-related cancers, and BMI-related cancers increased.
Trends were similar after adjusting for demographics, comorbidities, and HIV-related factors. Our results highlight the need for better prevention strategies to reduce the incidence of NADCs, smoking-related cancers, and BMI-related cancers. Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy ART -eras. Poisson regression was used to assess temporal trends, adjusted for potential confounders.
Age-standardised IRs for overall cancer remained fairly constant over time 8. The incidence of ADCs 3. Cancer is a leading cause of death, both in the general population and in people with HIV, in industrialised countries [ 1 , 2 , 3 , 4 , 5 ]. Since the introduction of combination antiretroviral therapy ART , there has been improved survival for people with HIV, and increases in the CD4 count have led to a drastic reduction in the incidence of ADCs [ 9 , 10 , 11 , 12 , 13 , 14 ].
In contrast, a previous study in the Data Collection on Adverse events of Anti-HIV Drugs D:A:D collaboration showed that the incidence of NADCs remained stable from to amongst 41, individuals from across Europe, Australia, and the United States [ 15 ], with other studies showing an increase in the incidence of NADCs, although generally only based on follow-up until [ 2 , 13 , 16 ]. The reasons for changes in the incidence of NADCs are likely to be multifaceted.
An increased risk is likely attributable, at least in part, to the aging of the population as a result of an increased life expectancy of people with HIV [ 8 , 17 , 18 , 19 , 20 ].
