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Transplant candidates on the waiting list are increasingly challenged by the lack of organs. Most of the organs can only be kept viable within very limited timeframes e.
Donation after circulatory death DCD using extracorporeal membrane oxygenation ECMO can significantly enlarge the donor pool, organ yield per donor, and shelf life. Nevertheless, clinical attempts to recover organs for transplantation after uncontrolled DCD are extremely complex and hardly reproducible.
Therefore, as a preliminary strategy to fulfill this task, experimental protocols using feasible animal models are highly warranted.
The primary aim of the study was to develop a model of ECMO-based cadaver organ recovery in mice. The secondary aim was to assess blood gas parameters, cardiac activity as well as overall organ state.
