These guidelines were updated by the U. This new section has been added to provide guidance on ART management in people with HIV who are candidates or recipients of solid organ and hematopoietic cell transplants. The Panel emphasizes the importance of maintaining HIV viral suppression before and after a transplant. The addition of immunosuppressive therapy and prophylaxis against opportunistic infections to ART increases pill burden and the potential for drug—drug interactions and adverse effects.
Because of the complexities of medical management, the Panel recommends that people with HIV who require transplantation be managed by a multidisciplinary team before, during, and after transplant AIII. The regimens recommended by the Panel as initial ART for people with HIV include those that have demonstrated clinical efficacy, have a high barrier to resistance, are well tolerated, and can be given as once-daily therapy. The Panel made the following changes to the recommended initial ART regimens:.
Updates made to the Virologic Failure section include the following:. Updates made to the Optimizing Antiretroviral Therapy in the Setting of Viral Suppression section include the following:.
Updates made to the Adherence to the Continuum of Care section include the following:. Tables 24a through 24g have been updated with new PK data on interactions between ARV drugs and other drugs, including drugs that were approved by the U. The information in the brief version is excerpted directly from the full-text guidelines. The brief version is a compilation of the tables and boxed recommendations. Search Guidelines Guidelines search. Open Close.
What's New in the Guidelines. Updated September 12, Reviewed September 12, Several antiretroviral ARV regimens are no longer recommended as initial therapy due to higher pill burdens, more adverse effects, or a lower barrier to resistance than other ART regimens recommended by the Panel.
