Our research group focuses on different aspects of the formulation and characterization of nanomedicines for the delivery to the respiratory system, lung toxicology of nanoplastics and biophysical studies of colloids for membrane-related studies and drug delivery purposes. Plastic is exceptionally durable and can persist in the environment, where it undergoes slow degradation. When plastics degrade, they form microplastic and sub-micron-sized nanoplastic particles MNPs.
The burden of MNPs in the environment is currently unknown, due to a lack of analytical tools to measure MNPs in complex environmental matrices. Our role in the project is to optimise manufacturing methods to generate reference micro- and nanoplastics, which will then be sent to our project partners.
In addition, micro- and nanoplastics present in sea spray aerosol will be collected and investigated with cutting-edge analytical methods, such as AFM-IR, to understand respiratory exposure. To successfully treat lung diseases with anti-infectives given intrapulmonary the compound must be presented in a way that it should not diffuse quickly to the blood stream and avoid the toxicity of local accumulation.
According to the WHO, globally, an estimated The impacts include reductions between and in the number of people provided with treatment for drug-resistant TB and TB preventive treatment, and a fall in global spending on TB diagnostic, treatment and prevention services. The TB standard-of-care antibiotic treatment is required to be given for at least 6 months but is often accompanied by significant adverse effects, which can lead to premature termination of the therapy.
Thereby, the occurrence of antibiotic-resistant strains is promoted further hampering successful therapy. The aim of the project was use nanocarriers to improve therapies of antibiotic resistant tuberculosis. Dailey, Dr. Li conducted pharmacokinetics studies aiming to better understand if the antibitiocs when entrapped into nanocarriers can have an advantage when administered via inhalation.
