Official websites use. Share sensitive information only on official, secure websites. For commercial re-use, please contact reprints oup. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals. Invasive fungal infections IFIs are severe and difficult-to-treat infections affecting immunocompromised patients.
Antifungal drug penetration at the site of infection is critical for outcome and may be difficult to achieve. Data about antifungal drug distribution in infected human tissues under real circumstances of IFI are scarce. Multiple samples were obtained from soft tissue abscesses of a lung transplant patient with Candida albicans invasive candidiasis who underwent recurrent procedures of drainage, while receiving different consecutive courses of antifungal therapy [itraconazole ITC , fluconazole, caspofungin].
The concentration within the infected tissue was interpreted as appropriate if it was equal or superior to the MIC of the causal pathogen. Variable concentrations were observed in the surrounding tissue of the lesions with median R of 2. Concentrations ranges within the fluid content of the abscesses were 0. This unique dataset of antifungal drug penetration in infected human soft tissue abscesses suggests that ITC, fluconazole and caspofungin could achieve appropriate concentrations in soft tissue abscesses.
Invasive fungal infections are frequent complications in immunocompromised patients. This later point is particularly critical for outcome. Our knowledge about antifungal drug penetration is mainly derived from animal models and human data are scarce. The adjustment of antifungal drug dosing often relies on therapeutic drug monitoring TDM of plasma trough concentrations, which is recommended for some triazoles voriconazole, posaconazole.
A limited set of clinical data suggests that antifungal drug penetration in deep abscesses may be quite low. The aim of the present study was to measure and compare the concentrations of different antifungal drugs in soft tissue abscesses from the same patient. This study was performed as part of a monocentric prospective observational study of antimicrobial drug penetration in tissue samples.
