Medpedia Podcast. Apps Newsletter Abo-Shop. Springer Medizin. Suche Suchbegriffe eingeben Suchen. Abstract Background 6-Gingerol 6-G is the primary active phytocomponent of ginger and has been shown to regulate multiple targets against cancer and its treatment. Androgen receptors ARs remain critical in the progression of prostate cancer PCa. This study focuses on investigating 6-G as a promising anti-cancerous agent that inhibits AR activity significantly.
Further in vitro study was done to evaluate the antioxidant, anti-cancerous, apoptotic, and wound healing potential of 6-G. Conclusions Thus, this study validates 6-G as a potential drug candidate against human PCa.
However, further study of the anticancer potency of 6-G has to be done before its use for PCa treatment. AR Androgen receptor. Bid B H3- i nteracting domain d eath agonist. Bcl-2 B-cell lymphoma 2. XIAP X-linked inhibitor of apoptosis protein. BT Bicalutamide. MTT 3- 4,5-dimethylthiazolyl -2,5-diphenyltetrazolium bromide. MMP Matrix metalloproteinase. DAPI Diamidinophenylindole dihydrochloride. LGA Lamarckian genetic algorithm. DFT Density functional theory. FMOs Frontier molecular orbitals.
HOMO Highest occupied molecular orbital. LUMO Lowest unoccupied molecular orbital. NBMO Non-bonding molecular orbital. QCP Quantum chemical parameter. PPB Plasma protein binding. BBB Blood-brain barrier.
P-gp P-glycoprotein. CNS Central nervous system. HIA Human intestinal absorption. GPCR G-protein coupled receptor. ICM Ion channel modulator. KI Kinase inhibitor. NRL Nuclear receptor ligand. PI Protease inhibitor.
