Official websites use. Share sensitive information only on official, secure websites. Corresponding author: Dror Marchaim; Email: drormarchaim gmail. A beta-lactam antibiotics BLA allergy label is common, resulting in disadvantageous outcomes due to the usage of second-line antimicrobial agents. The study aims were to explore predictors and outcomes associated with hypersensitivity reactions following BLA challenge among BLA-allergic labeled inpatients.
Independent predictors to develop allergic reactions and the independent associations of allergic reactions with clinical outcomes were queried by logistic and Cox regressions. Only 30 patients 2. Independent predictors to develop an allergic reaction were documented reactions in the past, atopic background, antihistamines administration prior to the BLA challenge, and high risk for cross-reactivity, based on the BLA side chains, between the labeled and the challenged agents.
Reaction upon the BLA challenge was not independently associated with any worse outcome. Despite the commonality of allergy labeling, and the commonality of BLA administration to labeled inpatients, hypersensitivity reactions were mild and rare. Beta-lactam antibiotics BLA are among the oldest and most commonly prescribed drugs worldwide. A retrospective cohort study was executed at Shamir Assaf Harofeh Medical Center SMC , central Israel, a university-affiliated bed acute-care institution, for calendar years β The study was approved by the local ethical institutional review board prior to its initiation.
If a patient was treated with the same BLA class during different hospitalizations, we included and captured only the first hospitalization. The severity of adverse reactions was graded according to the World Allergy Organization anaphylaxis guidelines.
Out-of-hospital mortality data was retrieved from the Israeli Ministry of Interior records. To avoid confounding, morbidity outcomes were analyzed among survivors only. During the study period, there were 14, hospitalizations of 9, adult patients at SMC. The mean age of patients was Of the cohort of 1, patients, there were 30 patients 2.
