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No use, distribution or reproduction is permitted which does not comply with these terms. A predictive model to estimate post-donation glomerular filtration rate eGFR and risk of CKD at 1-year was developed from a Toulouse-Rangueil cohort in and showed an excellent correlation to the observed 1-year post-donation eGFR. We retrospectively analyzed all living donor kidney transplants performed at a single center from to The model was successfully validated in our cohort, a different European population.
It represents a simple and accurate tool to assist in evaluating potential donors. Keywords: external validation, predictive model, living donor renal function, kidney transplantation, chronic kidney disease.
Living donor kidney transplant is the best treatment for ESRD patients eligible for transplant 1 , 2. Living donation increases organ availability, decreases time on the waiting list, allows pre-emptive transplantation, and improves graft and patient survival 1 — 3.
Despite being the only surgical indication that grants no direct medical benefit to a healthy patient, a living nephrectomy is considered a safe procedure for the donor 5 — 7. Long-term follow-up data, however, have shown that donors are at an increased risk of CKD and, rarely, ESRD compared to healthy non-donors 6 — 9 As such, these patients would be subjected to the cardiovascular and global morbidity and mortality of CKD Moreover, the scarcity of good-quality studies on their long-term follow-up must be acknowledged 6 , 7.
