Ulla I. E-mail: laura. Pathogens including viruses, bacteria, fungi, and parasites continue to shape our lives in profound ways every day. As we have learned to live in parallel with pathogens, we have gained a better understanding of the rules of engagement for how they bind, adhere, and invade host cells. This knowledge has led to the development of glycan-based diagnostics and therapeutics for the treatment and prevention of infection.
One class of compounds that has become increasingly important are the glycopolymers. Glycopolymers are macromolecules composed of a synthetic scaffold presenting carbohydrates as side chain motifs. In this review, we highlight studies over the past ten years that have examined the role of glycopolymers in pathogen adhesion and host cell infection, biofilm formation and removal, and drug delivery with the aim of examining the direct effects of these macromolecules on pathogen engagement.
In addition, we also examine the role of glycopolymers as diagnostics for the detection and monitoring of pathogens. Working in the group of Prof.
After a postdoc, working with Prof. Rainer Haag and Prof. Beate Koksch, she joined the group of Prof. Laura Hartmann. Her research is centered around the development of novel chemical tools to understand the pathology of aberrant protein glycosylation. Miriam Hoffmann. Miriam Hoffmann received her M. Her master's thesis, completed under the supervision of Prof. Dr Laura Hartmann in the Institute of Organic and Macromolecular Chemistry, focused on the synthesis of glycomacromolecule-functionalized liposomes.
Her current doctoral work, which is also being completed under the direction of Prof. Dr Laura Hartmann, focuses on the synthesis and membrane presentation of sulfonated and sulfated glycomacromolecules. Stephan Schmidt. Stephan Schmidt studied chemistry and polymer science in Berlin and Potsdam. He is interested in interactive polymer materials, in providing insights for their biomedical applications and the underlying molecular mechanism mainly using atomic force microscopy and other microscopy techniques.
